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Hexarelin Research: Can it Protect the Pancreas?

Hexarelin Research: Can it Protect the Pancreas?

One of the biggest problems associated with most pharmaceuticals is toxicity. Toxicity tends to be relative to dose though. Many pharmaceuticals are beneficial and safe at low doses, but become dangerous at high doses. Unfortunately, high doses of certain pharmaceuticals are also necessary to produce an effect. If there were some way to protect the body while administering high doses of certain drugs, they could be made more effective. New evidence about the (non-pharmaceutical) peptide called hexarelin, a ghrelin analogue and growth hormone (GH) secretagogue, suggests that this 6-amino-acid-long peptide can protect the pancreas from high doses of the cancer medicine streptozotocin1. This news is not only important for cancer care, but opens up the possibility that other short peptides may be useful in protecting tissues and organs from toxic side effects of certain drugs.

The Toxicity Problem

All pharmaceuticals have the potential to be toxic. In fact, just about everything on the planet can be toxic if taken in a large enough quantity. The key with pharmaceuticals is to balance toxicity against positive effects. This is nowhere more apparent than with antibiotics.

Most antibiotics are safe at lower doses and downright deadly at higher doses. Unfortunately, many bacteria today are demonstrating resistance to antibiotics that could once successfully kill them. The resistance is relative though. The antibiotics will work, but must be used at higher doses than they were in the past. In some cases, a dose increase is safe and acceptable. In other cases, a high enough dose cannot be achieved without putting the patient at risk. What if we could protect animal cells with a peptide, but still leave bacteria susceptible to the antibiotic? What if we could administer a substance that allowed us to ratchet up the dose of medications as high as necessary without causing any serious harm? Hexarelin is providing the first clues as to how science might do just that. Read latest news at http://www.thejournal.ie/medicines-seizure-donegal-3279704-Mar2017/?utm_source=shortlink

The Protective Effects of Hexarelin

Streptozotocin is an anti-cancer drug used to treat pancreatic tumors. It is exceptionally effective against cancer, but is also extremely toxic to healthy cells in the pancreas. This problem is hardly unique to the treatment of pancreatic cancer though. In fact, most chemotherapeutic agents are highly toxic. The toxicity of these drugs is the reason that cancer treatment causes hair loss, gastrointestinal problems, bone issues, and even other cancers. If there were some way to protect healthy cells from the effects of chemotherapy, doses of the drugs could be increased and it would become easier to treat cancer.

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New research finds that hexarelin can protect pancreatic cells in rats from the effects of streptozotocin. Even more interesting was the fact that hexarelin was able to ameliorate damage already caused by streptozotocin1. These findings suggest that hexarelin may be useful not just in the protection of pancreatic cells during administration of chemotherapy, but also in the management of diabetes.

A great deal more research in animal models needs to be done, but the implications are clear. Short peptides can be manufactured to not only treat disease, but to ward off damage caused by other therapies. If scientists can modify these peptides so that they protect healthy cells and leave cancerous cells, bacteria, viruses, fungi, etc. vulnerable, then it will be possible to increase drug dosages and achieve better results without putting patients at risk.

The Hexarelin peptide is still under scientific research and is not yet approved for human use by the FDA.

Making Sense of Non-Prescription Pain Meds

Making Sense of Non-Prescription Pain Meds

Thanks to brand names and confusing marketing, your local pharmacy counter can be a confounding place to shop. For instance, Diphenhydramine  is sold as Benadryl, an allergy medicine, though we all know it also makes you sleepy. The same chemical is sold as a sleep aid (Sominex), and a motion-sickness cure (Dramamine). Imagine a customer taking one of each trying to treat insomnia, car sickness and allergies all at once, and sleeping for a week! checkout latest blog posted at http://www.whispers-fromabove.com/5-surprising-ways-nurture-bad-back/

OTC pain-relief medicines can be an equally confusing lot to pick through. Here are a few of the most common, how to tell them apart, and a few of the pros and cons of each.

Tylenol

A basic and simple remedy as old as Monsanto, Acetaminophen (usually branded Tylenol) blocks pain signals sent to the brain. It is fast acting, gentle on the stomach and is almost certain to remedy a minor headache.

But be careful! Statistics indicate that overuse/overdose of Tylenol can cause serious liver damage and organ malfunction, and has even been the cause of overdose fatalities. Never take more than the listed dosage, and never more than 1 or 2 times a day.

Ibuprofen

Ibuprofen is the generic term for several competing brand-name pain relievers, including Advil and Motrin. It is a slower-acting and more complicated drug – ibuprofen works to dampen nerves before they can send pain signals, leading to some dubious advertising claims. Those commercials that point a red arrow at an arm or a leg, and claim “Advil targets the source of your pain” are mostly nonsense. Ibuprofen works on all of your nerves at once – there’s no way for that little pill to know which knee you’re having soreness in. But ibuprofen is still a long-lasting and relatively safe remedy for minor aches.

Sodium Naproxen

The Naproxen brand name you are likely familiar with is Aleve, which works on your nerves but also your hormones to decrease the pain signals sent to the brain. It is extremely long-lasting, if not the “12” or “24” hour relief often promised in advertising. Naproxen has a few dangers – it has been known to be dangerous to those with a history of heart problems or strokes, and can cause stomach damage as well. If you suffer from ulcers or heart disease, try an alternative. Doctors also caution that it is unsafe for small children.

Future Research Possibilities

Many peptides are currently being researched for various health benefits. One synthetic peptide is called TB-500 also known as Thymosin Beta-4. It  Research studies have shown this peptide to help reduce daily soreness by repairing tissue and reducing inflammation of  joints. Scientific studies on animal research subjects have shown that TB-500 can help prevent adhesions, reduce swelling, inflammation and relax muscle spasms. This peptide is not yet approved for human consumption by the FDA.

Excedrin Migraine Tablets

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Excedrin and other brands offer “super charged” concoctions of acetaminophen, caffeine, and aspirin for a power-punch of blood thinning and pain-relief properties in a tablet, usually marketed for “severe back pain” in addition to migraine headaches. These pills will “get the job done” for short-term pain relief, but can come with side effects overnight, such as insomnia, stomach aches or nervous tension.

Our best advice? Save any use for a rainy day. It’s your last resort in an emergency – not a go-to medicine. Remember, the goal is to relieve pain as gently and safely as you can. Instead of compounding the issue, keep it safe and simple – you can treat your pain without regretting it later on.

5 Surprising Ways to Nurture a Bad Back

5 Surprising Ways to Nurture a Bad Back

U.S. Senator Rand Paul likes to tell a story about old-school political operative Tip O’ Neill on the campaign trail. Legend has it Tip returned to a small town in Delaware over a year after his previous visit, and spotted a friendly face in the crowd. “Hey there, Fred! How’s that bad back of yours? ” he asked. “I can’t believe you remembered my back problem, Tip,” the man replied. “But it’s doing a lot better!” continue reading at http://www.whispers-fromabove.com/hexarelin-research-can-protect-pancreas/

An aide took Tip aside and asked how he could possibly have remembered that “Fred” had a bad back. “Aw heck, everybody’s got a back problem,” O’Neill said.

The joke is funny – but to many of us (especially men over 40) it rings too true. Here are 5 strategies to help deal with that nagging back problem that (almost) everybody has.

Wear a Heat Wrap

Instead of popping pills, wear a disposable heat wrap around your lower back. Research studies have shown that people who wear heat wraps have 25 percent less back pain on average than those self-treating with over-the-counter pain drugs. Wraps increase blood flow, help heal tissue damage, and improve mobility.

Chondroitin Sulfate

Bad backs are often caused by arthritis. The compound chondroitin sulfate, known for years as a knee-pain medicine, has been shown in clinical trials to aid back pain sufferers. The medicine works long-term to rebuild damaged tissue and is safe to ingest daily.

Don’t be Afraid of the Gym

Back pain suffers can fall prey to a vicious cycle. Because activity can be painful, they shy away from exercise. That causes further problems. “When you fear and avoid pain, you’re more likely to fear and avoid strengthening and stretching exercises—the very exercises that can help you recover,” says lower-back specialist Steven George.

Try exercising anyway, and going just 10 or 15 percent past your pain threshold to help reduce heft and strengthen your back muscles. If you can walk on a treadmill for 5 minutes before feeling your back tighten in pain, try walking for 5 minutes and 30 seconds. The pain won’t last, and your back will be stronger and less susceptible to daily soreness.

Future Research Possibilities

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Peptides are synthetic versions of amino acid chains that occur naturally in the body and have been shown in scientific research studies to help lift energy levels, stimulate metabolism, and increase stamina. Scientific studies on animal research subjects have shown that peptides can help with weight loss, workout recovery, and even improve greater sexual endurance.  These products are still under research studies and they are not yet approved for human consumption by the FDA.

Listen to Soothing Music

Don’t laugh – a recent Austrian medical study concluded that those who listened to relaxing music every day for 3 weeks reported back pain a drastic 40 percent less than the control group.

Music and other relaxing activities draws attention from the pain, and helps reduce stress hormones and muscle tension. Make sure to choose the right album (or movie) and let your mind drift away – your back pain might just drift away with it.